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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: J Pain Symptom Manage. 2016 Feb 16;51(5):832–838. doi: 10.1016/j.jpainsymman.2015.12.316

Table 2.

Mixed Modeling of Weekly Change of Individual Symptom Burden Among Three Groups by Type of CXRT

3DCRT (151 observations)a IMRT (240 observations)a PBT (144 observations)a
Est SE P Est SE P Est SE P
During CXRT (weeks 1–7)
 Pain 0.43 0.09 < 0.001 0.44 0.08 < 0.001 0.20 0.08 0.024
 Sore throat 0.65 0.10 < 0.001 0.50 0.08 < 0.001 0.10b 0.06 0.097
 Fatigue 0.22 0.08 0.019 0.41 0.07 < 0.001 0.16 0.10 0.132
 Drowsiness 0.30 0.11 0.016 0.32 0.06 < 0.001 0.22 0.10 0.050
 Lack of appetite 0.48 0.12 < 0.001 0.36 0.08 < 0.001 0.16 0.11 0.151
 Disturbed sleep 0.15 0.12 0.249 0.06 0.08 0.409 0.02 0.11 0.826
Post-CXRT (weeks 7–12)
 Pain –0.14 0.14 0.308 –0.40 0.13 0.005 –0.10 0.10 0.341
 Sore throat –0.54 0.15 0.001 –0.37 0.12 0.004 –0.06 0.07 0.409
 Fatigue –0.14 0.08 0.093 –0.44 0.11 < 0.001 0.19 0.12 0.117
 Drowsiness –0.11 0.11 0.352 –0.31 0.10 0.003 –0.06 0.11 0.599
 Lack of appetite –0.48 0.14 0.002 –0.28 0.13 0.037 –0.13 0.13 0.317
 Disturbed sleep –0.30 0.13 0.030 –0.04 0.12 0.728 –0.03 0.12 0.796

3DCRT = three-dimensional conformal radiation therapy; CXRT = concurrent chemoradiation therapy; Est = estimate of the effect of independent variables (or factors) on symptoms; IMRT = intensity-modulated radiotherapy; PBT = proton-beam therapy; SE = standard error.

a

Age, sex, race, cancer stage, Eastern Cooperative Oncology Group performance status, body mass index, total radiation dose, previous chemotherapy, and previous surgery were included as covariates in all models. Estimate value represents the average weekly change in symptom score on the MDASI’s 0–10 scale, with a positive score indicating increased severity.

b

This item was worded as “mouth or throat sores” in the PBT group.