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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Arch Biochem Biophys. 2016 Mar 11;599:22–30. doi: 10.1016/j.abb.2016.03.008

Table 1.

Concentrations of xanthohumol (XN) and its metabolites isoxanthohumol (IX), 8-prenylnaringenin (8-PN), and 6-prenylnaringenin (6-PN) in liver and plasma. 8-PN was only detected in the liver and then only in very small amounts, and no 6-PN was detected in either the low or high dose group.

graphic file with name nihms771164u2.jpg
Plasma (nM) Liver (nmol/g)
Low Dose (30 mg/kg BW/day) n=16 XN 84.4 ± 8.5 0.477 ± 0.119
IX 3.1 ± 1.2 0.279 ± 0.070
8-PN ND* 0.010 ± 0.002
6-PN ND* ND*
Total 87.5 ± 9.2 0.766 ± 0.191
High Dose (60 mg/kg BW/day) n=16 XN 95.1 ± 13.4 0.805 ± 0.201
IX 13.6 ± 2.1 0.746 ± 0.186
8-PN ND* 0.006 ± 0.001
6-PN ND* ND*
Total 109 ± 14 1.56 ± 0.39
*

ND, not detectable.