Figure 1. Adaptive immunity plays a role in the anti-BCR-ABL+ B-ALL response.

A. Representative dot plots and histograms from five mice with varying leukemic burden (gated as live, singlet, CD19⁺, B220^low cells. Black curves are MHC-II, grey curves are isotype. Listed are the percentage of Live singlet events which fall into the CD19⁺, B220^low gate. B. Correlations of measured variables with first two principal components. PDL1, MHC-II, CD80, and CD86 correlate positively with PC1; CD40 and (to a lesser extent) CD86 correlate positively, while PDL1 correlates negatively, with PC2. C. Screeplots of Principal Components (PC). Y-axis shows proportion of variance accounted for by each PC. D. Distribution of individual mouse scores on PCs 1 and 2. Mouse leukemic burden is indicated by dot size and dot shade, larger white dots indicate mice with higher leukemic burden, and smaller black dots indicate mice with lower leukemic burden. E. Predicted leukemic burden as a function of PC2 scores at three separate levels of PC1 (low, average, and high). Grey regions denote 95% confidence bounds. Principal components were derived from 27 separate mice in 3 experiments.