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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Matrix Biol. 2016 Mar 3;52-54:339–354. doi: 10.1016/j.matbio.2016.03.001

Figure 2. Excessive chondrogenesis and chondroid bone forming in glenoid fossa of Prg4-null mice.

Figure 2

Parasagittal sections prepared from TMJs of 2 day- (A, J), 2 week- (B, K), 1 month- (C–G, L–P) and 5 month-old (H, I, Q, R) control (A–I) and Prg4−/− (J–R) mice were stained with Hematoxylin & Eosin (A–C, H–L, Q). Note that the thickened presumptive articular cartilage layer (pac) (K) resulted in the expansion of the chondrocyte progenitor layer (cp), chondrocyte layer (cl) and chondroid bone zone (cb) in Prg4−/− TMJs (L, Q) compared to controls (C, H). Sections were processed for in situ hybridization with isotope-labeled riboprobes for Col Iα2 (D, M), Col IIα1 (E, N), Ihh (F, O). Col X (G, P), Prg4 (I) and Sox9 (R). Scale bar: 55 μm in A for A–R.