Table 2.
Risk of Crohn’s disease according to quintiles of plasma inflammatory markers
| Q1 | Q2 | Q3 | Q4 | Q5 | Ptrend* | |
|---|---|---|---|---|---|---|
| IL6 (pg/ml) | ||||||
| NHS, median (range) | 0.56 (0.19–0.69) | 0.82 (0.69–0.96) | 1.15 (0.96–1.33) | 1.71 (1.34–2.22) | 3.48 (2.23–78.2) | |
| NHSII, median (range) | 0.46 (0.34–0.58) | 0.68 (0.59–0.81) | 0.95 (0.82–1.08) | 1.29 (1.08–1.72) | 2.44 (1.75–27.9) | |
| Number of cases/controls | 9/65 | 11/72 | 10/69 | 22/69 | 31/69 | |
| Unadjusted OR (95% CI) | Referent | 1.10 (0.43–2.83) | 1.05 (0.40–2.74) | 2.30 (0.99–5.37) | 3.25 (1.44–7.34) | <0.001 |
| Adjusted OR# (95% CI) | Referent | 1.18 (0.45–3.08) | 1.22 (0.46–3.28) | 2.92 (1.19–7.19) | 4.68 (1.91–11.46) | <0.001 |
| hsCRP (mg/l) | ||||||
| NHS, median (range) | 0.37 (0.07–0.59) | 0.89 (0.60–1.26) | 1.91 (1.29–2.54) | 3.66 (2.57–4.81) | 6.97 (4.93–36.7) | |
| NHSII, median (range) | 0.24 (0.03–0.38) | 0.62 (0.43–0.87) | 1.12 (0.89–1.49) | 2.38 (1.50–4.04) | 8.60 (4.05–23.3) | |
| Number of cases/controls | 11/68 | 15/70 | 15/69 | 20/69 | 22/68 | |
| Unadjusted OR (95% CI) | Referent | 1.33 (0.57–3.09) | 1.34 (0.58–3.14) | 1.79 (0.80–4.02) | 2.00 (0.90–4.44) | 0.079 |
| Adjusted OR# (95% CI) | Referent | 1.36 (0.58–3.22) | 1.51 (0.62–3.63) | 2.22 (0.94–5.27) | 2.82 (1.15–6.87) | 0.019 |
*
The P value for linear trend was generated using an ordinal variable based on the median value for each quintile of IL6 or hsCRP.
#
Multivariable models adjusted for cohort, age, smoking status, body mass index, oral contraceptive use, and cumulative physical activity.
CI, confidence interval; NHS, Nurses’ Health Study; NHSII, Nurses’ Health Study II; OR, odds ratio; Q1–5, inflammatory marker quintiles.