Table 2.
Time for 10% of Men Without Osteoporosisa or Treatment at Baseline to Develop Osteoporosis, According to Baseline T-score Range
| Baseline T-score range | Osteoporosis events, N (%) | Time interval for 10% of participants to develop osteoporosisb | |
|---|---|---|---|
| Unadjusted years (95% CI) | Adjusted years (95% CI) | ||
| >−1.50 | 9/4203(0.21) | ---- | ---- |
| −1.50 to −1.99 | 35/680 (5.15) | 8.57 (6.67, 10.99) | 8.51 (6.67, 10.86) |
| −2.00 to −2.49 | 73/352 (20.74) | 2.59 (2.03, 3.30) | 2.68 (2.12, 3.40) |
Osteoporosis defined as lowest T-score ≤-2.5 at femoral neck or total hip or lumbar spine, calculated using bone mineral density (BMD) norms for young white women
Estimated time to osteoporosis (competing risks: incident hip or clinical vertebral fracture, antifracture treatment or death), computed by quantile estimates based on the fitted log logistic models, stratified by baseline lowest femoral neck, total hip or lumbar spine T-score (lowest T-score −1.50 to −1.99 vs. −2.00 vs. −2.49), and adjusted for mean-centered age, mean-centered BMI and race.
Note: Time estimates for the T-score>−1.50 group could not be calculated due the very small number of endpoint events, leading to excessive extrapolation beyond the observed BMD follow-up of 8.7 years.