Table 2.
Pharmacokinetic parameter estimates
| Parameter | Estimate | (RSE%) | IIV CV% | (RSE%) | Shrinkage (%) |
|---|---|---|---|---|---|
| CL/F (L/h) | 0.423 | (3.9) | 15.6 | (12.7) | −1.05 |
| V/F (L) | 24.30 | (4.6) | 18.4 | (14.4) | 2.80 |
| k tr (h−1) | 0.329 | (17.0) | 83.4 | (24.1) | 24.6 |
| k a (h−1) | 0.148 | (13.2) | |||
| FSHbl (µg/L) | 0.162 | (9.1) | 27.8 | (16.5) | 5.51 |
| Progblef | −0.246 | (34.7) | |||
| InhBef | 100 | (37.2) |
Typical population parameter estimates obtained from modelling
For CL/F and V/F the value is the typical value for a woman weighing 65 kg
RSE relative standard error, IIV interindividual variability, CV coefficient of variation, F bioavailability, CL/F apparent clearance, V/F apparent volume of distribution, k tr absorption rate from the dosing site, k a absorption rate from the transit compartment, FSH bl endogenous follicle-stimulating hormone baseline, Progbl ef power exponent for progesterone baseline covariate effect, InhB ef inhibin B time-varying covariate effect