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. 2016 Apr 30;16(2):165–172. doi: 10.1007/s40268-016-0126-z
The multiple-dose pharmacokinetics of FE 999049 have been described, accounting for endogenous follicle-stimulating hormone (FSH) levels.
Exposure to FE 999049 was influenced by body weight, which may be a potential factor for individualised dosing recommendations.
Endogenous FSH levels were influenced by progesterone and inhibin B levels. This time-varying contribution of endogenous FSH may be important to consider when characterising the pharmacokinetics of recombinant FSH products.