The multiple-dose pharmacokinetics of FE 999049 have been described, accounting for endogenous follicle-stimulating hormone (FSH) levels. |
Exposure to FE 999049 was influenced by body weight, which may be a potential factor for individualised dosing recommendations. |
Endogenous FSH levels were influenced by progesterone and inhibin B levels. This time-varying contribution of endogenous FSH may be important to consider when characterising the pharmacokinetics of recombinant FSH products. |