Table 2.
Pharmacokinetic parameter estimates
| Parameter | Estimate | (RSE %) | IIV CV % | (RSE %) | Shrinkage (%) |
|---|---|---|---|---|---|
| CL/F (L/h) | 0.430 | (6.3) | 28.2 | (29.5) | 5.31 |
| V/F (L) | 28.0 | (9.1) | 44.3 | (20.7) | 4.82 |
| k tr (h−1) | 0.517 | (24.8) | |||
| k a (h−1) | 0.160 | (12.9) | 23.3 | (27.8) | 31.8 |
| Additive error (µg/L) | 0.038 | (26.1) | |||
| Proportional error (µg/L) | 0.033 | (64.9) |
Typical population pharmacokinetic parameter estimates and residual error estimates obtained from modelling with the RSE calculated from the NONMEM covariance step in brackets
For CL/F and V/F, the value is the typical value for a woman weighing 65 kg
CL/F apparent clearance, CV coefficient of variation, F bioavailability, IIV interindividual variability, k a absorption rate to the central compartment, k tr absorption rate from the dosing site to the transit compartment, RSE relative standard error, V/F apparent volume of distribution