Table 6.
Ninety percent confidence intervals of ln-transformed pharmacokinetic parameters between the administration of levetiracetam 3DP fast melt under fed conditions vs. levetiracetam 3DP fast melt under fasting conditions in healthy volunteers
Parameter | Ratio (fed/fast) | 90 % confidence intervals | |
---|---|---|---|
Lower | Upper | ||
lnC max | 63.85 | 59.79 | 68.19 |
lnAUC0–T | 94.45 | 92.58 | 96.36 |
lnAUC0–∞ | 94.93 | 93.00 | 96.89 |
3DP three-dimensional printing, AUC 0–T area under the plasma concentration–time curve from time zero to the time of the last measurable concentration, AUC 0–∞ area under the plasma concentration–time curve from time zero to infinity, C max maximum observed plasma concentration, ln natural logarithm