Table 3.

Summary of renal clearance (CL_R) and apparent total plasma clearance (CL/F) of edoxaban, presented by renal function [17]

Parameter	Normal: CLCR >80 mL/min; N = 8	Mild impairment: CLCR ≥50–≤80 mL/min; N = 8	Moderate impairment: CLCR ≥30–<50 mL/min; N = 8	Severe impairment: CLCR <30 mL/min; N = 8
C max (ng/mL)	84.7 ± 26.4	113 ± 48.9	115 ± 42.3	91.9 ± 32.8
AUC∞ (ng·h/mL)	453 ± 102	636 ± 152	816 ± 209	857 ± 199
CLR (L/h)	11.9 ± 1.88	7.68 ± 2.57	4.30 ± 1.72	2.12 ± 0.88
CL/F (L/h)	34.6 ± 7.32	24.8 ± 6.00	19.4 ± 4.69	18.5 ± 4.87

Data are presented as mean ± standard deviation

AUC _∞ area under the concentration–time curve extrapolated from time zero to infinity, CL _CR creatinine clearance, C _max maximum observed plasma drug concentration