Table 2.

Detailed descriptions of immunocompromised patients in analysis.

Case ID	Age (years)	Gender	PIM3 predicted mortality (percent)	Cause of immunocompromised state	Coinfections	MODS	ARDS	RRT	ECLS	Antiviral therapy	Case fatality
1	3	M	5.334	Hematopoetic stem cell transplant—allogeneic due to SCID, no GVHD; immunomodulators: mycophenolate mofetil, methylprednisolone, and cyclosporine	RSV, HRV/EV, and Alpha hemolytic Streptococcus in blood culture	Yes	No	Yes	No	Cidofovir, acyclovir	Yes
2	3	F	7.04	Neutropenia (ANC = 140/mm3) due to AML	HRV/EV	Yes	Yes	No	No	None	Yes
3	2	F	15.4	Hematopoetic stem cell transplant—liver, pancreas, and small bowel; immunomodulators: methylprednisolone	Enterobacter respiratory infection	Yes	Yes	Yes	Yes	Cidofovir, ganciclovir, investigational medication INV-CMX001 (liposomal cidofovir)	Yes
4	14	F	5.3	Hematopoetic stem cell transplant—allogeneic due to AML, possible GVHD; immunomodulators: mycophenolate mofetil and cyclosporine	None	Yes	Yes	Yes	No	Cidofovir, acyclovir, ganciclovir, and valacyclovir	Yes
5	18	F	5.6	Hematopoetic stem cell transplant—allogeneic due to Pre-B Cell ALL, no GVHD; immunomodulators: cyclosporine and methotrexate	HRV/EV	Yes	Yes	Yes	No	Cidofovir, acyclovir	Yes
6	2	F	5.5	Hematopoetic stem cell transplant—autologous due to relapsed retinoblastoma, no GVHD; immunomodulators: none	None	No	No	No	No	Acyclovir	No
7	2	M	1.3	Neutropenia (ANC 360/mm3) due to hemophagocytic lymphohistiocytosis	None	Yes	No	Yes	No	None	Yes
8	3	M	1.2	Neutropenia (ANC 0/mm3) due to Langerhans cell histiocytosis	None	No	No	No	No	Foscarnet, ganciclovir	No
9	1	F	0.14	Transient hypogammaglobulinemia of infancy	HRV/EV	No	No	No	No	None	No
10	5	M	1.1	Solid organ transplant—kidney; immunomodulators: prednisone, tacrolimus	HRV/EV	No	No	No	No	Valganciclovir	No
11	12	F	5.3	Hematopoetic stem cell transplant—allogeneic due to severe aplastic anemia, grade IV GVHD; immunomodulators: methylprednisolone, daclizumab, infliximab, and mycophenolate	None	Yes	No	Yes	No	Cidofovir, investigational medication INV-CMX001 (liposomal cidofovir)	Yes
12	4	F	6.5	Hematopoetic stem cell transplant—autologous due to neuroblastoma, no GVHD; immunomodulators: none	None	Yes	Yes	No	No	Cidofovir	Yes
13	11	M	5.4	Hematopoetic stem cell transplant—allogeneic due to AML, GVHD; immunomodulators: mycophenolate mofetil, and prednisolone	None	Yes	Yes	Yes	No	Cidofovir, ribavirin	Yes
14	4	F	5.8	Hematopoetic stem cell transplant—allogeneic due to SCID variant, no GVHD; immunomodulators: cyclosporine and mycophenolate mofetil	None	Yes	No	No	No	Cidofovir, foscarnet, and cytogam	Yes
15	3	F	5.4	Hematopoetic stem cell transplant—allogeneic for Sickle Cell Disease, GVHD grade IV; immunomodulators: Methylprednisolone, Extracorporeal photopheresis, tacrolimus, cyclosporine, infliximab, rituximab, and mycophenolate mofetil	None	No	No	No	No	Cidofovir, brincidofovir, and acyclovir	Yes
16	<1	M	1.1	DiGeorge Syndrome	None	No	No	No	No	None	No
17	13	F	1.1	Solid organ transplant—kidney; immunomodulators: prednisone, cellcept, and rapamune	None	Yes	Yes	No	No	Cidofovir	No
18	17	M	1.2	Wiscott-Aldrich Syndrome	HRV/EV	No	No	No	No	None	No
19	8	M	1	Common variable immune deficiency	HRV/EV, Alpha hemolytic Streptococcus from BAL sample	No	No	No	No	None	No

AML: acute myeloid leukemia; ANC: absolute neutrophil count; ALL: acute lymphoblastic leukemia; ARDS: acute respiratory distress syndrome; BAL: bronchoalveolar lavage; ECLS: extracorporeal life support; GVHD: graft-versus-host disease; HRV/EV: human rhino-/enterovirus; MODS: multiple organ dysfunction syndrome; RRT: renal replacement therapy; RSV: respiratory syncytial virus; SCID: severe combined immunodeficiency.