(a).
| Early caffeine (1-2 DOL) |
Late caffeine (3–7 DOL) |
p value | |
|---|---|---|---|
| N | 85 | 46 | |
| GA (wks) | 26.34 ± 1.84 | 26.41 ± 1.80 | p = 0.53 |
| BW (g) | 891.78 ± 227.50 | 909.13 ± 243.92 | p = 0.69 |
| Sex (female/male) | 38/47 (44.7%, 55.3%) | 28/18 (60.9%, 39.1%) | p = 0.10 |
|
| |||
| Short-term clinical assessment | |||
| Duration of NICU stay | 79.79 ± 30.51 | 76.73 ± 25.43 | p = 0.18 |
| BPD | 23 (27.1%) | 14 (30.4%) | p = 0.69 |
| ROP requiring surgery | 7 (8.2%) | 0 | p = 0.10 |
| RDS | 65 (76.5%) | 36 (78.3%) | p = 1.00 |
| PDA | 41 (48.2%) | 25 (54.3%) | p = 0.58 |
| PDA requiring ligation | 4 (4.7%) | 3 (6.5%) | p = 0.70 |
| Necrotizing enterocolitis | 8 (9.4%) | 5 (20%) | p = 0.39 |
| PVL | 4 (4.7%) | 0 | p = 0.30 |
DOL, days of life; BPD, bronchopulmonary dysplasia; ROP, retinopathy of prematurity; RDS, respiratory distress syndrome; PDA, patent ductus arteriosus; PVL, periventricular leukomalacia.