Figure 2.

Microglia and monocytes converge in high-grade glioma (HGG). HGG cells induce local inflammation that compromises the integrity of the blood-brain barrier (BBB) and results in Ly6C^hi CCR2⁺ CX3CR1^low/int monocytes infiltrating into the tumor¹⁴. Once in the CNS, these cells can differentiate into tumor-associated macrophages and become nearly indistinguishable from activated resident microglia. Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2015. All rights reserved.