Table 1.
Cardiac Parkin, PINK1, and Mfn2 mRNA levels from public RNA-Seq data
| Source tissue | Park2 FPKM | Pink1 FPKM | Mfn2 FPKM | NCBI GEO |
|---|---|---|---|---|
| Nonfailing human heart (8) | 5.2 | 79.1 | 117.0 | GSE46224 |
| Illumina Human Body Map 2.0, human heart HCT20143 (1) | 5.9 | 66.1 | 97.2 | GSE30611 |
| Illumina Human Body Map 2.0, human brain HCT20160 (1) | 3.5 | 64.7 | 26.3 | GSE30611 |
| E13.5 mouse heart (7) | 0.6 | 35.3 | 63.4 | GSE58455 |
| P1 mouse heart (6) | 1.4 | 86.2 | 163.7 | GSE68921 |
| P21 mouse heart (3) | 1.3 | 229.6 | 265.5 | GSE68921 |
| 5 week-old mouse heart (4) | 1.6 | 272.1 | 292.5 | GSE68921 |
| Sham-operated mouse heart (5) | 1.6 | 247.2 | 241.0 | GSE29446 |
| Sham-operated mouse heart (4) | 1.5 | 182.3 | 207.4 | GSE35350 |
| 17 week-old mouse heart (6) | 1.4 | 88.8 | 66.7 | GSE73909 |
| Adult mouse heart (pooled) | 1.3 | 146.4 | 158.4 | GSE49906 |
| Isolated adult mouse cardiac myocytes (pooled) | 1.1 | 325.7 | 265.3 | GSE49906 |
| Isolated adult mouse cardiac fibroblasts (pooled) | 0.9 | 15.9 | 7.0 | GSE49906 |
Data are RNA-Seq expression in FPKM (fragments per kilobase of exon per million fragments mapped); FPKM of 3 = approximately 1 mRNA copy/cell. NCBI Gene Expression Omnibus data set sources for each interrogation are provided. Numerals in parentheses indicate number of biological replicates. Pink1 is formerly known as Park6. Mfn2 is phosphorylated by PINK1 to become a mitochondrial outer membrane receptor for Parkin.