Table 1.
Characteristics of patients with lung adenocarcinoma (N=28)
| Characteristics | n | % |
|---|---|---|
| Sex | ||
| Male | 7 | 25.0 |
| Female | 21 | 75.0 |
| Smoking history | ||
| Yes | 4 | 14.3 |
| No | 24 | 85.7 |
| ECOG | ||
| 0 | 15 | 53.6 |
| 1 | 9 | 32.1 |
| 2 | 4 | 14.3 |
| GPA | ||
| 0–1.5 | 11 | 39.3 |
| 2–3 | 17 | 60.7 |
| EGFR status | ||
| Mutation | 12 | 42.9 |
| Wild-type | 14 | 50.0 |
| Unknown | 2 | 7.1 |
| Treatment | ||
| Initial treatment | 11 | 39.3 |
| Retreatment | 17 | 60.7 |
| Site of first progression | ||
| Intracranial | 14 | 50.0 |
| Extracranial | 10 | 35.7 |
| Concurrent | 4 | 14.3 |
| Number of BMs | ||
| 1–3 | 19 | 67.9 |
| 4–10 | 5 | 17.9 |
| >10 | 4 | 14.3 |
| Extracranial metastases | ||
| Yes | 25 | 89.3 |
| No | 3 | 10.7 |
| Cerebral radiation | ||
| Before icotinib treatment | ||
| WBRT | 4 | 14.3 |
| SRT | 3 | 10.7 |
| During icotinib treatment | ||
| WBRT | 4 | 14.3 |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; GPA, Graded Prognostic Assessment; EGFR, epidermal growth factor receptor; BMs, brain metastases; WBRT, whole-brain radiation therapy; SRT, stereotactic radiation therapy.