Table A2.
Physiological results from Study 2
| Test | Drug | Time 0 h | Time 2 h | Time 4.5 h | Time 6.5 h |
|---|---|---|---|---|---|
| Intraocular pressure (mmHg) | Placebo | 10.1 (0.9) | 9.6 (0.7) | 9.5 (0.6) | 9.2 (0.4) |
| Acetazolamide 250 mg* | 10.4 (0.8) | 8.6 (0.6) | 8.1 (0.3) | 7.8 (0.6) | |
| Acetazolamide 1000 mg*** | 10.1 (0.8) | 7.7 (0.5) | 8.4 (0.6) | 7.2 (0.5) | |
| End‐tidal PCO2 (mmHg) | Placebo | 34.0 (1.3) | 34.4 (1.0) | 35.2 (1.1) | 35.5 (1.1) |
| Acetazolamide 250 mg | 34.3 (0.9) | 34.0 (1.1) | 34.7 (1.1) | 32.0 (0.9) | |
| Acetazolamide 1000 mg | 36.7 (1.2) | 33.5 (1.2) | 33.8 (1.0) | 32.1 (1.7) | |
| Blood pH | Placebo | 7.44 (0.01) | 7.44 (0.01) | 7.45 (0.01) | 7.45 (0.01) |
| Acetazolamide 250 mg** | 7.43 (0.00) | 7.40 (0.01) | 7.41 (0.01) | 7.39 (0.01) | |
| Acetazolamide 1000 mg*** | 7.42 (0.01) | 7.38 (0.01) | 7.39 (0.00) | 7.40 (0.01) | |
| Blood PCO2 | Placebo | 35.2 (0.8) | 34.8 (0.9) | 33.9 (1.0) | 34.5 (1.0) |
| Acetazolamide 250 mg | 35.2 (1.2) | 35.7 (1.0) | 35.7 (1.0) | 33.9 (0.8) | |
| Acetazolamide 1000 mg | 35.4 (0.9) | 34.3 (0.8) | 35.2 (0.6) | 32.8 (0.7) | |
| Blood bicarbonate (calculated) | Placebo | 23.7 (0.5) | 23.2 (0.4) | 23.1 (0.6) | 23.2 (0.5) |
| Acetazolamide 250 mg | 23.8 (0.6) | 22.4 (0.8) | 22.5 (0.6) | 19.8 (0.4) | |
| Acetazolamide 1000 mg** | 22.9 (0.6) | 20.1 (0.5) | 21.2 (0.4) | 20.1 (0.6) | |
| Simple Reaction time | Placebo | 233.9 (9.5) | 226.8 (9.4) | 221.3 (9.9) | 228.2 (9.9) |
| Acetazolamide 250 mg | 236.9 (13.7) | 235.3 (11.5) | 213.6 (9.2) | 222.0 (6.7) | |
| Acetazolamide 1000 mg | 221.6 (10.4) | 227.8 (9.8) | 207.2 (9.7) | 224.8 (7.7) | |
| Base Excess (mEq/L) | Placebo | −0.17 (0.523) | −1.120 (0.509) | −1.233 (0.693) | −0.907 (0.591) |
| Acetazolamide 250 mg* | −0.930 (0.700) | −3.05 (0.509) | −2.163 (0.831) | −5.267 (0.537) | |
| Acetazolamide 1000 mg*** | −0.446 (0.975) | −4.860 (0.509) | −3.715 (0.501) | −4.914 (0.781) | |
| Urine pH | Placebo | 6.0 (0.1) | 6.6 (0.15) | 6.6 (0.2) | 6.8 (0.1) |
| Acetazolamide 250 mg*** | 5.7 (0.1) | 7.7 (0.06) | 7. 9 (0.0) | 7.7 (0.0) | |
| Acetazolamide 1000 mg*** | 6.2 (0.2) | 7.7 (0.06) | 7.9 (0.0) | 7.7 (0.0) | |
| Urine volume (mL) | Placebo | 159 (28) | 238 (44) | 143 (22) | 147 (19) |
| Acetazolamide 250 mg | 88 (18) | 401 (45) | 268 (24) | 345 (24) | |
| Acetazolamide 1000 mg** | 126 (20) | 527 (46) | 382 (46) | 364 (23) |
*P < 0.05, **P < 0.01 ***P < 0.001 (relative to placebo). Values shown are mean ± SEM.