Table A3.
Physiological and psychometric results in Study 3
| Test | Drug | Time 0 h | Time 2 h | Time 4.5 h | Time 6.5 h |
|---|---|---|---|---|---|
| Urine pH | Placebo | 5.5 (0.1) | 5.9 (0.1) | 5.7 (0.1) | 6.1 (0.1) |
| Lorazepam | 5.6 (0.1) | 6.2 (0.1) | 6.2 (0.1) | 6.5 (0.2) | |
| Acetazolamide*** | 5.6 (0.2) | 7.5 (0.1) | 7.7 (0.1) | 7.4 (0.2) | |
| Benzolamide*** | 5.7 (0.1) | 7.5 (0.1) | 7.7 (0.1) | 7.5 (0.1) | |
| Urine vol (mL) | Placebo | 92 (21) | 211 (30) | 142 (26) | 145 (31) |
| Lorazepam | 65 (15) | 225 (38) | 132 (22) | 132 (20) | |
| Acetazolamide*** | 81 (16) | 358 (38) | 301 (36) | 238 (21) | |
| Benzolamide** | 100 (21) | 321 (36) | 265 (37) | 210 (24) | |
| CFF (Hz) | Placebo | 33.9 (0.9) | 33.6 (0.9) | 32.8 (0.8) | 32.9 (0.8) |
| Lorazepam*** | 33.7 (0.7) | 30.4 (0.9) | 32.6 (0.9) | 31.9 (1.0) | |
| Acetazolamide | 32.9 (1.0) | 33.3 (1.0) | 33.5 (0.9) | 33.4 (0.9) | |
| Benzolamide | 33.6 (0.6) | 33.0 (0.7) | 33.1 (0.7) | 32.3 (0.9) | |
| Sway (degrees) | Placebo | 0.53 (0.03) | 0.57 (0.04) | 0.57 (0.03) | 0.58 (0.04) |
| Lorazepam** | 0.56 (0.04) | 0.83 (0.05) | 0.69 (0.05) | 066 (0.04) | |
| Acetazolamide* | 0.53 (0.04) | 0.62 (0.03) | 0.62 (0.04) | 0.68 (0.06) | |
| Benzolamide | 0.53 (0.03) | 0.52 (0.03) | 0.60 (0.05) | 0.63 (0.05) | |
| Vertical error (sum of steps) | Placebo | 21.0 (3.1) | 23.7 (3.0) | 36.5 (5.6) | 27.1 (5.5) |
| Lorazepam* | 29.7 (5.7) | 32.8 (7.2) | 32.1 (6.9) | 41.9 (8.4) | |
| Acetazolamide* | 30.2 (3.9) | 44.3 (5.6) | 31.1 (2.9) | 30.3 (5.5) | |
| Benzolamide | 29.6 (3.9) | 27.1 (3.0) | 26.9 (3.3) | 30.4 (3.6) | |
| Pegs correctly placed in 2 min | Placebo | 34.5 (1.1) | 36.1 (1.3) | 34.7 (1.1) | 36.6 (1.2) |
| Lorazepam*** | 36.3 (1.0) | 28.9 (1.4) | 35.7 (1.9) | 33.9 (1.2) | |
| Acetazolamide | 34.1 (1.1) | 34.8 (1.3) | 35.0 (1.2) | 34.5 (1.5) | |
| Benzolamide | 33.7 (1.0) | 34.0 (1.0) | 34.0 (1.0) | 34.8 (1.2) | |
| VAS sleepy | Placebo | 66.8 (6.5) | 60.5 (6.2) | 65.1 (5.4) | 64.2 (6.1) |
| Lorazepam*** | 72.1 (6.4) | 40.8 (7.5) | 43.6 (7.7) | 47.8 (6.6) | |
| Acetazolamide* | 64.8 (6.6) | 51.7 (6.0) | 47.3 (6.1) | 42.8 (8.3) | |
| Benzolamide | 75.8 (5.5) | 68.3 (6.0) | 58.3 (7.4) | 64.8 (6.5) | |
| VAS clear headedness | Placebo | 23.3 (5.0) | 25.9 (3.9) | 28.6 (5.4) | 28.4 (5.3) |
| Lorazepam*** | 28.8 (6.8) | 53.1 (6.7) | 45.6 (6.6) | 38.4 (7.2) | |
| Acetazolamide*** | 30.6 (5.9) | 58.4 (5.2) | 54.3 (6.0) | 46.9 (7.1) | |
| Benzolamide | 17.3 (4.7) | 28.8 (6.5) | 35.2 (7.0) | 30.6 (6.7) | |
| VAS dizzy | Placebo | 80.9 (6.3) | 80.9 (4.6) | 73.3 (6.4) | 73.9 (6.2) |
| Lorazepam*** | 79.9 (5.8) | 31.8 (6.3) | 33.9 (6.1) | 56.1 (8.4) | |
| Acetazolamide*** | 72.5 (7.2) | 58.8 (8.2) | 53.8 (8.4) | 55.8 (7.8) | |
| Benzolamide | 87.5 (4.5) | 82.5 (5.0) | 74.7 (6.6) | 79.0 (6.1) | |
| VAS hungry | Placebo | 25.8 (5.7) | 51.8 (6.9) | 25.1 (5.3) | 36.1 (6.0) |
| Lorazepam | 28.8 (6.5) | 54.0 (7.1) | 25.4 (5.5) | 36.1 (5.9) | |
| Acetazolamide | 33.7 (6.7) | 49.9 (7.5) | 20.4 (4.4) | 35.3 (7.1) | |
| Benzolamide | 26.5 (5.3) | 51.6 (5.3) | 24.4 (5.2) | 35.5 (5.5) | |
| Intraocular pressure (mmHg) | Placebo | 9.8 (0.7) | 10.4 (0.6) | 9.0 (0.4) | 9.1 (0.4) |
| Lorazepam | 9.9 (0.6) | 9.3 (0.5) | 9.0 (0.5) | 8.9 (0.5) | |
| Acetazolamide** | 9.0 (0.6) | 7.7 (0.7) | 7.7 (0.5) | 8.3 (0.5) | |
| Benzolamide | 9.4 (0.6) | 8.5 (0.4) | 8.6 (0.5) | 8.7 (0.5) |
*P < 0.05, **P < 0.01, ***P < 0.001 (relative to placebo). Values are mean ± SEM.