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. 2016 Apr 21;4(3):e00235. doi: 10.1002/prp2.235

Figure 1.

Figure 1

Mitochondrial fusion and fission cycle and its key players. (A) Mitochondrial interconnectivity is maintained by fusion which is regulated by proteins such as Mfn1, Mfn2, Opa1, SLP2, and PLD. Mitochondrial fragmentation follows fission, governed by several factors including Fis1, MiD49/51, Mff, miR‐30, miR‐499, and Drp1. Mitochondrial fission is suppressed via inhibition of Drp1 by the synthetic small molecule Mdivi‐1. (B) Proposed binding orientation of Mdivi‐1 (green carbons, sticks) to Drp1 (gray, surface rendered). Mdivi‐1 was computationally docked onto the Drp1 crystal structure (Wenger et al. 2013) using default conditions for the Geom‐dock module in Sybyl‐X 2.1.1 (Certara L.P.). Shown is a representative of the highest scoring cluster of solutions. Drp1, dynamin‐related protein 1; Fis1, fission 1; Mff, mitochondrial fission factor; Mfn1, mitofusin 1; Mfn2, mitofusin 2; MiD49/51, mitochondrial dynamics protein‐49/51; miR30/499, micro‐RNA 30/499; Opa1, optic atrophy protein; PLD, phosphatidylcholine hydrolyzing phospholipase D; SLP2, stomatin like protein‐2.