Figure 2.
Pharmacodynamic profile of Mdivi‐1. Mdivi‐1 confers cytoprotection by employing a Drp1‐dependent inhibition of Bax/Bak‐mediated apoptosis, activating the RISK pathway, upregulating mitochondrial large conductance Ca2+and voltage activated K+ (Mito‐BK) channel as well as reducing ROS. Its cytotoxic effect is exerted independent of Drp1 and through activation of Noxa‐mediated apoptosis. Mdivi‐1 also exerts an inhibitory effect on hyperproliferative cells by inducing G2/M cell cycle arrest and impairs mitosis. Bak, Bcl2‐antagonist/killer 1; Bax, Bcl2‐associated X protein; DNA, deoxyribonucleic acid; Drp1, dynamin‐related protein 1; G2/M, second gap/mitosis; Mito‐BK, mitochondrial big potassium channel; RISK, reperfusion injury salvation kinase; ROS, reactive oxygen species.