Table 1.
Porcine haemodynamic measurements (mean (SD)).
| HR (beats min −1 ) | dP/dt max ( mmHg·s −1 ) | ESP (mmHg) | dP/dt min ( mmHg·s −1 ) | |||||
|---|---|---|---|---|---|---|---|---|
| Placebo | Rotigaptide | Placebo | Rotigatide | Placebo | Rotigaptide | Placebo | Rotigaptide | |
| Baseline | 66 (17) | 68 (13) | 1920 (367) | 2050 (504) | 127 (14) | 127 (14) | −2862 (835) | −2320 (562) |
| 0 min post‐ischaemia | 79 (26) | 66 (10) | 1655 (250) | 1503 (284) | 109 (12) | 108 (13) | −2284 (861) | −1846 (525) |
| 1 min post‐ischaemia | 152 (31) | 134 (23) | 1335 (358) | 1555 (817) | 108 (10) | 86 (22) | −1391 (541) | −1375 (789) |
| 5 min post‐ischaemia | 108 (28) | 114 (23) | 1736 (204) | 1502 (480) | 81 (15) | 93 (14) | −1898 (832) | −1676 (861) |
| 30 min post‐ischaemia | 104 (19) | 106 (20) | 1613 (197) | 1609 (383) | 86 (13) | 97 (10) | −1960 (665) | −1749 (559) |
| 60 min post‐ischaemia | 113 (14) | 99 (16) | 1515 (116) | 1623 (551) | 89 (11) | 100 (7) | −2056 (755) | −2129 (955) |
| 120 min post‐ischaemia | 88 (23) | 96 (21) | 1396 (266) | 1423 (338) | 101 (15) | 103 (8) | −2669 (1737) | −1888 (603) |
ESP, end‐systolic pressure; dP/dtmax, maximum positive pressure development over time; HR, heart rate; dP/dtmin, maximum negative pressure development over time. P = NS for all, placebo vs. rotigaptide (anova).