Table 3.
Efficacy of treating pain on psychosis and agitation in patients presenting one or more clinically significant symptoms at baseline (NPI-NH ≥ 4).
| Baseline (SD) | 8 weeks (SD) | ||||||
|---|---|---|---|---|---|---|---|
| Control (n = 71) | Intervention (n = 83) | p a | Control (n = 67) | Intervention (n = 70) | p a | p changeb | |
| Psychosis cluster | 10.5 (4.7) | 11.6 (5.9) | 0.314 | 6.4 (5.3) | 5.6 (6.1) | 0.148 | 0.034 |
| Delusion | 5.6 (4.2) | 6.9 (4.0) | 0.043 | 3.2 (3.7) | 2.9 (3.6) | 0.770 | 0.031 |
| Hallucination | 3.2 (3.8) | 3.3 (4.0) | 0.813 | 2.1 (3.1) | 2.1 (3.3) | 0.987 | 0.925 |
| Euphoria | 1.7 (2.9) | 1.4 (3.1) | 0.211 | 1.0 (2.2) | 0.5 (1.9) | 0.027 | 0.758 |
|
| |||||||
| Control (n = 128) | Intervention (n = 137) | p a | Control (n = 117) | Intervention (n = 113) | p a | p changeb | |
| Agitation cluster | 17.4 (9.7) | 18.0 (9.6) | 0.422 | 14.0 (11.0) | 8.8 (8.8) | <0.001 | <0.001 |
| Agitation/aggression | 4.7 (4.0) | 5.1 (4.2) | 0.441 | 4.2 (4.0) | 2.5 (3.3) | 0.001 | 0.004 |
| Disinhibition | 3.9 (4.3) | 3.5 (4.0) | 0.618 | 3.3 (4.2) | 1.9 (3.2) | 0.008 | 0.211 |
| Irritability | 4.8 (3.6) | 5.1 (4.1) | 0.664 | 3.6 (3.6) | 2.6 (3.2) | 0.023 | 0.183 |
| Abb. motor behaviour | 4.0 (4.7) | 4.3 (4.9) | 0.639 | 2.9 (3.9) | 1.8 (3.5) | 0.008 | 0.007 |
aCalculated by analyzing the difference between the intervention group and control group at each measurement point using the Mann-Whitney U test.
bCalculated by analyzing the difference in change of NPI-NH score in the intervention group versus the control group from baseline to Week 8 using the Mann-Whitney U test.