Table 1.
Patients Demographic and Clinical Characteristics
| Characteristic | Published Cohort (n = 1,556) |
Unpublished Cohort (n = 1,416) |
||
|---|---|---|---|---|
| No. | % | No. | % | |
| Age, years | ||||
| Median | 64 | 63 | ||
| IQR | 56-71 | 55-71 | ||
| Male sex | 961 | 62 | 898 | 63 |
| Year of diagnosis | ||||
| Median | 2003 | 2007 | ||
| IQR | 1998-2005 | 2002-2009 | ||
| Follow-up, years* | ||||
| Median | 6.9† | 4.0† | ||
| Range | 0-36 | 0-43 | ||
| Deaths | 324† | 21 | 171† | 12 |
| Stage‡ | ||||
| Early | 843 | 55 | 823 | 58 |
| Intermediate | 568 | 37 | 513 | 36 |
| Advanced | 134† | 9 | 75† | 5 |
| ALC, × 109/L | ||||
| Median | 15 | 13 | ||
| IQR | 9-34 | 8-27 | ||
| B-ALC, × 109/L | ||||
| Median | 10 | 9 | ||
| IQR | 5-19 | 5-17 | ||
| β2M > ULN | 544 | 52 | 439 | 57 |
| del11q | 120 | 9 | 103 | 10 |
| del17p | 75 | 6 | 75 | 7 |
| Unmutated IGHV | 487 | 37 | 478 | 42 |
| ZAP-70 positive | 449 | 40 | 555 | 40 |
| CD38+ | 464 | 31 | 406 | 29 |
| CD49d+ | 587 | 38 | 511 | 36 |
| OS | ||||
| 5 year | 90 | 92 | ||
| 10 year | 73 | 80 | ||
| TFS | ||||
| 5 year | 57 | 59 | ||
| 10 year | 39 | 42 | ||
NOTE. Differences between published and unpublished cohorts were evaluated using χ2 or Wilcoxon test.
Abbreviations: ALC, absolute lymphocyte count; B-ALC, absolute B-cell count; β2M, β2-microglobulin; IQR, interquartile range; OS, overall survival; TFS, treatment-free survival; ULN, upper limit of normal.
*
Estimated by inverted censoring.
†
P < .01.
‡
Early stage, Binet A or Rai 0; intermediate stage, Binet B or Rai I to II; advanced stage, Binet C or Rai III to IV.