Table 2.
Multivariable Cox Regression Analysis of OS
| Factor | Final Reduced Model |
Initial Full Model |
Univariate Model |
||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Age > 65 years | 3.25 | 2.18 to 4.84 | < .001 | 3.03 | 2.00 to 4.57 | < .001 | 2.75 | 1.87 to 4.02 | < .001 |
| Unmutated IGHV | 2.48 | 1.68 to 3.66 | < .001 | 1.99 | 1.29 to 3.07 | < .001 | 2.64 | 1.81 to 3.85 | < .001 |
| CD49d ≥ 30% | 2.26 | 1.57 to 3.25 | < .001 | 2.01 | 1.36 to 2.97 | < .001 | 2.31 | 1.62 to 3.29 | < .001 |
| del17p | 2.13 | 1.37 to 3.32 | < .001 | 2.22 | 1.41 to 3.50 | < .001 | 2.90 | 1.87 to 4.49 | < .001 |
| Male sex | 1.83 | 1.24 to 2.69 | .0022 | 1.73 | 1.18 to 2.56 | .0055 | 1.53 | 1.06 to 2.22 | .0241 |
| ALC > 15 × 109/L | 1.66 | 1.11 to 2.48 | .0133 | 1.62 | 1.08 to 2.43 | .0202 | 1.55 | 1.05 to 2.30 | .0290 |
| ZAP-70 | — | — | — | 1.45 | 0.95 to 2.21 | .0864 | 2.27 | 1.57 to 3.27 | < .001 |
| β2M > ULN | — | — | — | 1.26 | 0.80 to 1.97 | .3217 | 2.23 | 1.47 to 3.40 | < .001 |
| CD38 | — | — | — | 1.21 | 0.82 to 1.78 | .3447 | 1.98 | 1.38 to 2.82 | < .001 |
| del11q | — | — | — | 1.19 | 0.70 to 2.04 | .5244 | 1.35 | 0.82 to 2.23 | .24 |
NOTE. Final model was multivariable analysis with backward stepwise elimination of nonsignificant predictors. All models were stratified by study site and clinical stage. Total patient cases included, 1,117; events, 137.
Abbreviations: ALC, absolute lymphocyte count; β2M, β2-microglobulin; HR, hazard ratio; OS, overall survival; ULN, upper limit of normal.