Skip to main content
. 2016 May 23;6:26521. doi: 10.1038/srep26521

Figure 2. Kinetics and selectivity of NPD7155 and NPD9948.

Figure 2

(a,b) Kinetic analysis of NPD7155 (7155) and NPD9948 (9948) against MTH1. Lineweaver–Burk plot of reciprocal of initial velocity vs. reciprocal of varying 8-oxo-dGTP concentrations (a) and Dixon plot of reciprocal of initial velocity vs. varying concentrations of NPD7155 or NPD9948 (b). Data are shown as mean ± s.e.m. from three independent experiments. (c) Effects of NPD7155, NPD9948, TH287, (S)-crizotinib [(S)-CZT], and SCH51344 (SCH) on the catalytic activities of ITPA and DCTPP1 in vitro. Data are shown as mean ± s.d. from three independent experiments.