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. 2016 May 23;6:26450. doi: 10.1038/srep26450

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(a) The unfolding free energy landscape of pY88-p27 from CDK2/CyclinA complex with associated color scale. Representative structures of the three major states are shown - the bound state (state-B), intermediate state (state-I), and unfolded state (state-U). (b) The 1D free-energy profiles of p27 unbinding based on C_α-RMSD of its β-strand (dashed lines) and 3₁₀ helix (solid line) as obtained from Boltzmann reweighting distribution.