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. 2016 May 23;6:26633. doi: 10.1038/srep26633

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(a) 8-OH-DPAT as a prototypical 5-HT_1A agonist. (b) MPPF as a 5-HT_1A “silent antagonist” (without any activation). (c) F13714 as a 5-HT_1A biased agonist. (d) F15599 as a 5-HT_1A biased agonist. Colours indicate the chronology of activation (yellow, T1; orange, T2; red, T3; purple, T4; blue, T5).