Table 2. Univariable Analysis and Bivariable Cox Regressions.
| Univariable Analysis and Bivariable Cox Regressions | CTCs | DTCs | ||
|---|---|---|---|---|
| Univariable Analysis | PFS | OS | PFS | OS |
| CTCs | 2.058 [1.106–3.828); p = 0.023 | 1.588 [0.702–3.595], p = 0.2671 | – | – |
| DTCs | – | – | 0.916 [0.564–1.487], p = 0.722 | 0.885 [0.481–1.630], p = 0.695 |
| Bivariable Analysis | ||||
| Histology | ||||
| Ductal Subtype | 1.728 [0.822–3.634], p = 0.149 | 1.405 [0.505–3.905], p = 0.515 | 0.802 [0.459–1.402], p = 0.439 | 0.688 [0.326–1.452], p = 0.326 |
| Lobular Subtype | 4.621 [1.227–17.405], p = 0.024 | 3.540 [0.705–17.787], p = 0.125 | 2.011 [0.539–7.502], p = 0.298 | 3.114 [0.570–17.027], p = 0.190 |
| Grading | ||||
| G1 | 1.281 [0.143–11.477], p = 0.825 | 2.588 [0.234–28.567], p = 0.438 | 2.324 [0.469–11.521], p = 0.302 | 2.426 [0.342–17.235], p = 0.376 |
| G2 | 2.353 [1.023–5.410], p = 0.044 | 1.540 [0.542–4.379], p = 0.418 | 0.695 [0.347–1.392], p = 0.305 | 0.490 [0.201–1.193], p = 0.116 |
| G3 | 1.929 [0.679–5.482], p = 0.218 | 1.329 [0.274–6.435], p = 0.724 | 0.915 [0.434–1.928], p = 0.815 | 1.335 [0.496–3.596], p = 0.567 |
| IHC-Subtype | ||||
| ER+ and or PR+/HER2− | 2.096 [0.949–4.628], p = 0.067 | 1.466 [0.472–4.553]; p = 0.508 | 1.126 [0.611–2.074], p = 0.704 | 1.039 [0.454–2.377], p = 0.929 |
| ER+ and or PR+/HER2+ | n.a., no events CTC+ | n.a., no events CTC+ | 0.454 [0.088–2.345], p = 0.346 | 0.752 [0.125–4.510], p = 0.755 |
| HER2+/ER−/PR− | 3.671 [0.694–19.420], p = 0.126 | 1.128 [0.12–10.206], p = 0.915 | 0.123 [0.032–0.481], p = 0.003 | 0.056 [0.007–0.465], p = 0.008 |
| Triple-negative | 8.565 [1.897–38.661], p = 0.005 | 7.924 [1.315–47.769], p = 0.024 | 1.660 [0.446–6.185], p = 0.450 | 2.229 [0.533–9.331], p = 0.272 |
| Radiotherapy | ||||
| (yes) | 2.434 [1.165–5.087],p = 0.018 | 2.121 [0.860–5.231], p = 0.103 | 0.937 [0.526–1.671], p = 0.827 | 1.165 [0.590–2.300], p = 0.660 |
| (no) | 1.059 [0.205–5.467], p = 0.945 | n.a., no events CTC+ | 2.113 [0.596–7.494], p = 0.247 | 0.894 [0.149–5.356], p = 0.903 |
| Hormone Receptor | ||||
| (pos) | 1.529 [0.707–3.304], p = 0.281 | 1.066 [0.353–3.217], p = 0.910 | 0.950 [0.526–1.715], p = 0.865 | 0.829 [0.375–1.835], p = 0.644 |
| (neg) | 6.910 [2.188–21.823], p = 0.001 | 4.310 [1.150–16.123], p = 0.030 | 0.708 [0.293–1.709], p = 0.442 | 0.889 [0.333–2.370], p = 0.814 |
| Menopausal status | ||||
| Post | 2.270 [1.183–4.453], p = 0.014 | 1.850 [0.802–4.266], p = 0.149 | 0.722 [0.410–1.270], p = 0.258 | 0.850 [0.433–1.667], p = 0.636 |
| Prä | 1.187 [0.123–11.453], p = 0.882 | n.a., no events CTC+ | 2.271 [0.601–8.576], p = 0.226 | 1.194 [0.199–7.165], p = 0.847 |
n.a. not applicable.
Hazard ratio (p-value); presented HR are estimated for DTC+/CTC + cases within respective subgroup [=row] from Cox regression model.