For cell line groups 2 (i.e., NEU, NPC, MCF7, ASC, A549, SKB), 3 (i.e., A549, ASC, SKB, MCF7, NPC, PHH), 4 (i.e., A549, HT29, MCF7, PC3, VCAP, A375), and 5 (i.e., HCC515, HA1E, PC3, VCAP, SKB, NPC, MCF7, ASC, A549); common compounds classified according to the number of differentially expressed genes at 24 h of incubation. (A, C, E, G) Significance based on individual cell lines in the respective group; (B, D, F, H) cumulative significance across the cell line group ordered by distance from the other cell lines based on all linear discriminant axes.