Table 2. Potential biomarkers.
| Potential biomarker | P-value | FC | VIP | FDR |
|---|---|---|---|---|
| carbamic acid, monoammonium salt | 0.00917 | 0.192485 | 14.8788 | 0.02769 |
| l-alanine ethylamide, (S)- | 0.04368 | 0.104253 | 1.02574 | 0.09202 |
| guanidine, N,N-dimethyl- | 0.00004 | 0.660394 | 2.41899 | 0.00049 |
| phosphonic acid, (p-hydroxyphenyl)- | 0.00027 | 0.104253 | 1.62293 | 0.00170 |
Abbreviations: VIP, variable importance in the projection, FC, fold change, defined as: FC = log10(X2/X1), where X1 denoted the arithmetic mean value of a certain metabolite in the case group and X2 denoted the arithmetic mean value in the control group. FC with a positive value indicates that the concentration of a certain metabolite is relatively higher in CSM patients controls compared with ALS patients; FDR, false discovery rate.