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. 2016 May 23;6:26052. doi: 10.1038/srep26052

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One tentative model that may explain the contribution of sAPPα in an anabolic cascade relies on LNRGF activity in oligodendrocytes as an sAPPα receptor. ADAM17 is one of the α-secretases, which processes APP in the anabolic pathway, producing sAPPα. LNRGF is a receptor for sAPPα. LNRGF activation upregulates mature oligodendrocytes, which then produce additional ADAM17. A breakdown in regulation of this cycle may lead to out-of-control looping that produces excessive sAPPα, which contributes to autism symptoms.