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Quiescent epidermal cells in adult fly epidermis endoreplicate in response to injury. In response to injury, quiescent epidermal cells surrounding a puncture wound enter S phase and become ready labeled with the S phase marker EdU at 2 days postinjury. These EdU+cells grow instead of dividing by entering the endocycle. Shown is an immunofluorescent image of the wound zone with EdU+cells in white. The wound site is outlined by the magenta dashed line.
