Figure 2.

Regeneration after fragmentation. (A) Drawing showing a typical three-fourth fragment of a wing imaginal disc. (B) Drawing showing a cut in a wing imaginal disc. (C) Red dots represent proliferating cells. Proliferation is concentrated near the wound edges before and after the wound closes.^26–28 (D) JNK signaling and Wg expression occur near the wound.^{4,22,23,30,39,40} Other putative regeneration genes include myc, matrix metalloproteinase 1 (mmp1), regeneration (rgn), augmenter of liver regeneration (alr), cabut, and ash2.^4,40,45 (E) Cells have been specified to be vein (purple) or intervein (orange). (F) After fragmentation, vein and intervein markers are no longer expressed near the wound.¹³ JNK, Jun N-terminal kinase; Wg, wingless. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound