Figure 3.
Regeneration after tissue ablation. (A) Drawing showing area targeted for ablation in brown, which is almost the entire wing primordium, as defined by the expression domain of the gene rotund.4 (B) Drawing showing area targeted for ablation in brown, as defined by the expression domain of the gene spalt major.5 (C) Red dots represent proliferating cells. Proliferation is concentrated near the ablation site.4,5 (D) JNK signaling and Yki activation, as well as Wg, Myc, and CycE are important for regenerative growth after tissue ablation.4,5,31 Other putative regeneration genes include ajuba, capicua, fat, and crumbs.4,32,48 (E) After ablation of an entire intervein (orange) between two veins (purple), the vein cells proliferate and change fate to replace the lost intervein cells.48 Yki, Yorkie. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/wound