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. 2016 Apr 28;6(7):969–985. doi: 10.7150/thno.14856

Figure 1.

Figure 1

CuAAC-mediated Au NPs-implemented nanosensors for detection of Cu(II) in solution-based assay. (A) Azide-and alkyne-functionalized Au NPs can be triggered to aggregate in the presence of Cu (I) by CuAAC, and the degree of color change of AuNPs is related to the concentration of Cu(II). (B) Schematic depiction of the copper-triggered aggregation of AuNPs for Cu (II) detection. (C) The colorimetric method for detection of Cu (I) based on densely functionalized DNA-Au NP conjugates and CuAAC. (D) The unmodified Au NPs combines with “alkyne-azide” clickable DNA probe for detection of Cu (II). Adapted with permission from [42, 70, 85, 86].