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. 2016 Apr 28;6(7):1012–1022. doi: 10.7150/thno.15095

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Effect of rHuPH20 modification on RBCM-NP blood circulation. A) The rHuPH20 activity on PH20-RBCM-NPs remained after quenching unreacted thiol and maleimide groups on modified RBCs with PEG_2K-maleimide and PEG_2K-thiol sequentially in NP fabrication. B) In vivo blood circulation of DiD-labeled PH20-RBCM-NPs and RBCM-NPs via measuring the fluorescence intensity of NPs. PLGA-PEG-NPs were tested as a control. Value indicates mean ± s.d. (n = 6 from two independent experiments). Inset: Semi-log scale NP signals with time in which the slope illustrates circulation half-life. The circulation half-lives for RBCM-NPs and PH20-RBCM-NPs were fitted into a two-compartment model, while the half-life for PLGA-PEG-NPs was fitted into a one-compartment model.