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. 2016 Apr 28;6(7):1065–1074. doi: 10.7150/thno.15420

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Stability study of nanostructures formed by dCPT-K₂ (a), dCPT-OEG₅-K₂ (b) and dCPT-Sup35-K₂ (c) after dilution to 50 μM, 12.5 μM and 3.125 μM in water, as monitored by CD. All the diluted solutions were aged over three days before CD measurements. Corresponding CD results showed no significant changes for both dCPT-K₂ and dCPT-OEG₅-K₂. However, a slight decrease in signal of nanofibers formed by dCPT-Sup35-K₂ was observed, indicating partial dissociation of the supramolecular nanostructures into smaller aggregates and/or prodrug monomers.