Table 4. Mutation Sites in the HBV Pre-S/S Genes of 15 Mother-Newborn Pairs Within the Vaccination Failure Groupa.
| Case | Different Mutation Sites (Wild Type Nucleotide Sites → Mutated Nucleotide Sites) | |||||
|---|---|---|---|---|---|---|
| Mother | Newborn | Infant at 7 Months | ||||
| ORF | Non-ORF | ORF | Non-ORF | ORF | Non-ORF | |
| 1 | ntG190G/A; ntT216T/C; ntG285G/A; ntC573T; | ntT972T/C | - | nt G1131A | - | nt G1131A |
| 2 | - | ntC1139A | - | nt1138dupA | - | ntC1139A |
| 3 | - | ntA895A/T | - | ntA895T | - | ntA895T |
| 4 | - | - | - | ntC512C/T | - | |
| 5 | - | - | - | - | ||
| 6 | ntG381G/A; ntT814TC | - | - | - | - | - |
| 7 | nt A355G; nt A499G | - | ntA355A/GntA499A/G | - | ntA273A/G; ntA355A/G; ntA499A/G | - |
| 8 | - | - | - | - | - | - |
| 9 | - | - | - | - | - | - |
| 10 | ntA273A/G; ntG330G/A; ntA530A/G; ntG909G/A | - | 0 | 0 | ntG167G/A; ntA636A/T | - |
| 11 | - | nt1166het-dupC | - | - | - | - |
| 12 | - | - | - | - | - | - |
| 13 | - | - | - | ntC1173T | - | ntC1173T |
| 14 | ntC234C/T; ntC371C/G; ntA636A/T; ntT897T/C | - | 0 | 0 | ntC234T; ntC371G; ntA636T | - |
| 15 | - | - | - | - | - | - |
Abbreviations: -, no different mutation; 0, lower bounds for detection.
aThe counting nucleotides were based on site of EcoRIrestriction enzyme.