Table 2.

Activity of selected nitrothiazoles against wild type and TbNTR overexpressing T. b. brucei parasites in the presence of tetracycline (+tet).

Compound	IC50 value (μM) T.b. brucei			Ratio
Wild type	TbNTR (−tet)	TbNTR (+tet)	–tet/+tet
nfx	3.980 ± 0.150	6.359 ± 0.119	0.869 ± 0.046	7.3
3	1.019 ± 0.045	1.460 ± 0.113	0.526 ± 0.024	2.8
5	1.365 ± 0.091	1.957 ± 0.101	0.747 ± 0.075	2.6
6	1.474 ± 0.104	1.638 ± 0.069	0.636 ± 0.022	2.6
7	21.575 ± 3.630	–	–	–
8	1.612 ± 0.396	4.587 ± 0.149	2.176 ± 0.085	2.1
11	3.753 ± 0.383	3.249 ± 0.142	2.200 ± 0.100	1.5