Table 1.
Palbociclib pharmacokinetic parameters for 2/1 schedule and 3/1 schedule
| Pharmacokinetic parameter | 2/1 Schedule (SS, dose 200 mg) | 3/1 Schedule (SS, dose 125 mg) |
|---|---|---|
| Tmax, h | 4.2 | 5.5 |
| Vz/F, L | 3,241 | 2,793 |
| T1/2, h | 26.7 | 26 |
| CL/F, L/h | 88.5 | 80.6 |
| Rac | 2.4 | 2.2 |
| Reference | Schwartz et al65 | Flaherty et al66 |
Notes: Tmax, time to maximum plasma concentration; Vz/F, apparent volume of distribution; T1/2, elimination half-life; CL/F, apparent clearance; Rac, accumulation ratio; 3/1 Schedule, 3 weeks once daily and 1 week off treatment; 2/1 Schedule, 2 weeks once daily and 1 week off treatment.
Abbreviations: h, hours; SS, steady state.