Table 1.

Genes implicated in risk of early-onset Alzheimer’s disease

Gene symbol	Location	Function	Pathway	References
APP	21q21.3	Neuronal development, Synaptic formation and repair, β-Amyloid production	APP processing	13–15,18
PSEN1	14q24.3	γ-Secretase activity, Intracellular signaling, β-Amyloid production	APP processing	9,26,27
PSEN2	lq42.13	γ-Secretase activity, β-Amyloid production, Synaptic plasticity	APP processing	13,27,36