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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: Endocr Pract. 2010 Nov-Dec;16(Suppl 3):1–37. doi: 10.4158/ep.16.s3.1

Table 1.

2010 American Association of Clinical Endocrinologists Criteria for Rating of Published Evidencea

Numerical descriptor
(evidence level)
Semantic descriptor
(reference methods)
1 Meta-analysis of randomized controlled trials
1 Randomized controlled trial
2   Meta-analysis of nonrandomized prospective or case-
  controlled trials
2   Nonrandomized controlled trial
2   Prospective cohort study
2   Retrospective case-control study
3   Cross-sectional study
3   Surveillance study (registries, surveys, epidemiologic
  study)
3   Consecutive case series
3   Single case reports
4   No evidence (theory, opinion, consensus, or review)
a

1 = strong evidence; 2 = intermediate evidence; 3 = weak evidence; 4 = no evidence. From Mechanick et al (1).