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Per2 is required to maintain expression of CD133 stem cell marker. Lin−CD34highCD45mid cells were treated with siRNAs specific to the clock genes clock, Bmal1, Per2, and Cry2 or a scrambled/control siRNA, and surface expression for CD133 was determined using flow cytometry. Bar chart showing that only Per2 is necessary to maintain primitive stem cell characteristics compared with the other clock genes Clock, Bmal1, and Cry2. n = 8. ns, not significant.
