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. 2015 Aug 17;64(12):4112–4122. doi: 10.2337/db14-0810

Figure 2.

Figure 2

Insulin secretion and content under normal and proinflammatory conditions in ΔF508 mutant islets. Insulin secretion (A), insulin content (B), and insulin secretion normalized by insulin content (C) as assessed in 1-h static incubations in isolated islets from 14-week-old ΔF508 mutant and WT mice in response to 2.8 or 16.7 mmol/L glucose (G) after a 24-h exposure to 16.7 mmol/L glucose in the presence or absence of 1 ng/mL interleukin-1β plus 5 ng/mL interferon-γ. Data are mean ± SEM of 5 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001.