Table 1.
SF (n = 10) | HFD (n = 13) | SY (n = 12) | |
---|---|---|---|
Body weight (g) before administration | 44.00±1.06 | 54.83±2.26a | 53.00±2.03 |
Body weight (g) after administration# | 44.97±0.90 | 56.72±2.19a | 54.36±3.16 |
Subcutaneous fat mass (g) | 0.33±0.11 | 1.69±0.84a | 0.97±0.65b |
Mesenteric fat mass (g) | 0.63±0.22 | 1.18±0.57a | 0.85±0.40 |
Perirenal fat mass (g) | 0.25±0.07 | 1.12±0.59a | 0.67±0.36b |
Epididymal fat mass (g) | 0.64±0.14 | 2.22±0.85a | 1.67±0.80 |
Total fat mass (g) | 1.85±0.14 | 6.21±0.71a | 4.16±0.58b |
Percentage of fat mass* (%) | 4.70±0.31 | 11.91±1.01a | 8.41±0.96b |
FBG (mmol/L) | 5.22±0.75 | 8.00±0.78a | 5.83±0.68b |
UA (μmol/L) | 191.90±7.25 | 195.08±12.85 | 264.83±24.10b |
TC (mmol/L) | 4.25±0.32 | 4.90±0.27 | 4.76±0.30 |
TG (mmol/L) | 0.43±0.05 | 0.40±0.07 | 0.50±0.05 |
HDL-c (mmol/L) | 2.23±0.13 | 2.33±0.12 | 2.22±0.10 |
LDL-c (mmol/L) | 0.47±0.08 | 0.54±0.05 | 0.60±0.05 |
Lp(a) (mg/L) | 4.10±0.53 | 4.77±0.47 | 5.67±0.38 |
hsCRP (mg/L) | 0.08±0.01 | 0.08±0.01 | 0.09±0.01 |
FFA (μmol/L) | 1287.50±109.83 | 1129.85±82.66 | 1201.67±66.08 |
Insulin (ng/ml) | 0.47±0.05 | 0.52±0.06 | 0.73±0.11 |
Values are means ± SE; SF, standard food; HFD, high fat diet; SY, safflower yellow; FBG, fasting blood glucose; UA, uric acid; TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; Lp(a), lipoprotein (a); hsCRP, high-sensitivity C-reactive protein; FFA, free fatty acids;
,body weight after administration for 8 weeks;
, Total fat mass/Body weight;
,compared with SF group, P < 0.05;
,compared with HFD group, P < 0.05.