Table 1.

Effects of SY on body weight, body fat contents and biochemical parameters in HFD-induced obese mice.

	SF (n = 10)	HFD (n = 13)	SY (n = 12)
Body weight (g) before administration	44.00±1.06	54.83±2.26a	53.00±2.03
Body weight (g) after administration#	44.97±0.90	56.72±2.19a	54.36±3.16
Subcutaneous fat mass (g)	0.33±0.11	1.69±0.84a	0.97±0.65b
Mesenteric fat mass (g)	0.63±0.22	1.18±0.57a	0.85±0.40
Perirenal fat mass (g)	0.25±0.07	1.12±0.59a	0.67±0.36b
Epididymal fat mass (g)	0.64±0.14	2.22±0.85a	1.67±0.80
Total fat mass (g)	1.85±0.14	6.21±0.71a	4.16±0.58b
Percentage of fat mass* (%)	4.70±0.31	11.91±1.01a	8.41±0.96b
FBG (mmol/L)	5.22±0.75	8.00±0.78a	5.83±0.68b
UA (μmol/L)	191.90±7.25	195.08±12.85	264.83±24.10b
TC (mmol/L)	4.25±0.32	4.90±0.27	4.76±0.30
TG (mmol/L)	0.43±0.05	0.40±0.07	0.50±0.05
HDL-c (mmol/L)	2.23±0.13	2.33±0.12	2.22±0.10
LDL-c (mmol/L)	0.47±0.08	0.54±0.05	0.60±0.05
Lp(a) (mg/L)	4.10±0.53	4.77±0.47	5.67±0.38
hsCRP (mg/L)	0.08±0.01	0.08±0.01	0.09±0.01
FFA (μmol/L)	1287.50±109.83	1129.85±82.66	1201.67±66.08
Insulin (ng/ml)	0.47±0.05	0.52±0.06	0.73±0.11

Values are means ± SE; SF, standard food; HFD, high fat diet; SY, safflower yellow; FBG, fasting blood glucose; UA, uric acid; TC, total cholesterol; TG, triglycerides; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; Lp(a), lipoprotein (a); hsCRP, high-sensitivity C-reactive protein; FFA, free fatty acids;

^#,body weight after administration for 8 weeks;

^*, Total fat mass/Body weight;

^a,compared with SF group, P < 0.05;

^b,compared with HFD group, P < 0.05.