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. Author manuscript; available in PMC: 2016 May 23.
Published in final edited form as: Science. 2015 Sep 18;349(6254):1338–1343. doi: 10.1126/science.aac5017

Fig. 1.

Fig. 1

Genetic analyses of the DENV panel (n=47). (A) Phylogenetic tree showing the evolutionary relationships of DENV E gene sequences. Sequences were aligned with MAFFT, and a maximum likelihood tree (ML) was estimated using a general time reversible model, accounting for both among site rate variation and invariant sites (GTR+G4+I). Bootstrap support values of at least 75% are shown. (B) Amino acid map of dengue E protein sequences (493-495 amino acids in length). The total amino acid differences between pairs of E sequences correspond to distances between points on the geometric display.