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. Author manuscript; available in PMC: 2016 Oct 16.
Published in final edited form as: ACS Chem Biol. 2015 Jul 30;10(10):2267–2276. doi: 10.1021/acschembio.5b00265

Figure 8.

Figure 8

Schematic overview of miR-544/ATM/mTOR signaling axis. Overview of miR-544 signaling pathways under hypoxic conditions. Small molecule inhibition of miR-544 results in dysregulation of hypoxia-associated survival mechanisms leading to apoptosis through failure to adapt to low oxygen microenvironment.