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. Author manuscript; available in PMC: 2017 May 19.
Published in final edited form as: Cell Chem Biol. 2016 Apr 28;23(5):608–617. doi: 10.1016/j.chembiol.2016.03.015

Fig 1. Outline of T. brucei IP pathway.

Fig 1

Arrows indicate enzyme reactions with enzymes manipulated in the present study indicated in green and italicized. Open circles, essential genes; closed circles, nonessential genes; blue, overexpressed genes; red, knockdown or nulls in chemogenetic experiments. A gray square indicates an enzyme whose activity has not been studied or a gene essentiality that has not been analyzed. The red circles with white asterisks indicate TbSYJ1 which is annotated as synaptojanin (N-terminal domain) and is predicted to be a PI/IP 5-phosphatase. At least two genes encode enzymes with TbPIP5K, TbPIP5Pase and TbIMPase predicted activity. Annotation is based on predicted or demonstrated function (Table 1).