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. Author manuscript; available in PMC: 2017 May 19.
Published in final edited form as: Cell Chem Biol. 2016 Apr 28;23(5):608–617. doi: 10.1016/j.chembiol.2016.03.015

Fig 2. T. brucei IP pathway genes are essential for infection of mice.

Fig 2

A) Parasitemia with CN cell lines. Mice were infected with 1.0×104 parasites and parasitemia was counted daily by tail prick. Dox = 200 µg/ml, n = 3 mice per group except for TbPIP5K in which n = 6 mice per group. B) Mouse survival after infection with CN cell lines from A. C) Mouse infection with SM427 or null cell lines. Experiments as in A except that mice did not receive dox, n = 3 per group. D) Mouse survival after SM427 or null cell lines infection from C. Mice were euthanized if parasitemia reached ≥ 1.0×108 parasites/ml. Data are represented as mean ± SEM.