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. Author manuscript; available in PMC: 2017 May 19.
Published in final edited form as: Cell Chem Biol. 2016 Apr 28;23(5):608–617. doi: 10.1016/j.chembiol.2016.03.015

Fig 4. Chemogenetic analysis.

Fig 4

A) Heatmap showing fold changes in compound sensitivity of overexpressing or null/CN cell lines compared to parental (SM427) or noninduced cells. The subset of compounds with EC50 <~1.5 µM was used for analysis. PMD, pentamidine. B–C) Fold EC50 changes for each compound in each overexpressing cell line (B) or CN/null cell line (C). A FDR of 1% was used as a cutoff (gray shading). NIDs are indicated for some compounds which EC50 changes. A list of compounds and genes showing significant changes by chemogenetic analysis with p ≤ 0.05 by ANOVA are shown on the right of each graph (see details in Table S2). Data are represented as mean.